Full Publication Of Randomized Scandinavian Dose Escalation Trial For LS SCLC
03 Mar, 2021
Dr. Rajesh Bollam
45Gy / 30 Fx / 3 weeks vs 60Gy / 40 Fx / 4 weeks
2a OS 74.2% vs 48.1%
Med OS 37.2 mo vs 22.6 mo
Med PFS 18.6 mo vs 10.9 mo (p=0.13)
Grade 3+ toxicity and SAEs
First benefit of dose escalation in NSCLC / SCLC since SBRT for stage I NSCLC
Discussion
- Phase II
- Long term OS not yet available
- OS in control arm comparable to literature
- Lack of PFS & LC benefit due to difficult image interpretation ?
- FDG-PET staging & TV definition
#DrRajeshBollam #oncologistinyashoda #hematolgist #HematoOncologist #lungcancerdoctor #radiationdose #SCLC
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